Diplomate: American Board of Emergency Medicine
Diplomate: American Board of Internal Medicine
Emergency Physician: Kaiser Permanente, Northern California, retired
Research Associate (1981-1986): Stanford University, Computer Science Dept. and co-Principal Investigator of the RX Project (Stanford University)
Awards from NIH: NLM, NCHSR; NSF; PHS; PReMA; RWJ Fnd; Toyobo Fnd;
PhD: Computer Science and Biostatistics: Stanford University - 1981 The RX Project: Automated Medical Discovery - 1976 to 1986
Post-Doctoral Fellow: Clinical Pharmacology: Stanford University (1976 to 1979)
House Staff and Chief Resident: Internal Medicine: Kaiser Northern California
MD: University of California, San Francisco (MSTP: neuroscience) Regent Scholar
B Sci: Massachusetts Institute of Technology (mathematics) and Hertz Engineering Scholar
I've been fascinated by the neurobiology of consciousness for fifty years.
How is it possible for neural circuits to produce pain, pleasure, and our entire perceived world?
Consciousness is the master illusion — the engineering product of hundreds of millions of years of evolution.
This is an outstanding work by one of the world's top researchers of consciousness. Since the death of William James and the ascent of Watson, Thorndike, and Skinner, consciousness all but disappeared (as a field of study) from American cognitive neuroscience. Europeans, especially the brilliant Stan Dehaene, are leading the current revitalization.
Living in Silicon Valley, I'm used to watching Google's self-driving cars dodge me as I ride around town on my electric bike. But, are they conscious?
No (not yet!) But, here I address what it will take to make them conscious — and, why would you bother? Also, what's the difference between machine vision and mammalian visual perception? Led by advances in neuroscience, computer vision researchers are rapidly accelerating (but have quite a ways to go.)
Two new videos have just appeared in the prestigious journal Science. The first is an animation showing the incredible level of detail at the synapse. The second video, based on hundreds of electron micrographs stitched together, shows the impossibly complex ultrastructure of the neuropil: the impenetrable forest surrounding synapses.
The key question is — how much of that fine detail must be modeled to replicate the brain's performance? My confident assertion is that much more is required than is incorporated into current brain-inspired AI models. (Multi-layer convolutional neural nets are just a start — even when combined with reinforcement learning.)
Attaining such supernal wisdom may entail understanding the entirety of the internet — not to mention hundreds of billions of real-time sensors. It will also entail advances in AI not yet even envisioned.
A byproduct may be the AI's ability to autonomously create Nobel-level science and engineering in many fields. This will not happen in my lifetime and possibly not even in yours.
Would this be desirable for planet Earth and our biosphere? Possibly, yes! Humanity's unchecked proliferation, uninformed by long-term sustainability, has been an unmitigated disaster for our biosphere.
Some SETI/Fermi Paradox cognoscenti believe there's a Great Filter that rids the Universe of technological civilizations, eg by nuclear annihilation or by crafty, rampaging AI. With regard to that, it seems to me more likely that superintelligent AI may eventually provide humanity with wise counsel and enhance our survival, rather than terminating us maliciously. They might ultimately be as good at steering civilization as they are at steering driverless cars.
I'm on the Science Advisory Board of the Brain Preservation Foundation (BPF), which seeks to advance the state of the art by awarding cash prizes for best research. So, what are the prospects? I haven't signed up with Alcor, but ask me again in 2030.
Here, neuroscience MD, PhD candidate Andy McKenzie elicits my opinions. In brief: molecular whole brain preservation may be possible by 2040. Resurrection in silicon may not be possible (if ever) until well after 2100. So, keep eating vegetables and exercising — that's my best advice for now!
By the way, we just awarded our BPF small mammal cash prize to Robert McIntyre, who spearheaded the team at 21st Century Medicine. If you want to see the state of art, get his paper "Aldehyde Stabilized Cryopreservation" in Cryobiology.
2018 Update: Robert McIntyre also founded Nectome, a company promoting end-of-life euthanasia to facilitate brain preservation for the purpose of future brain uploading. He had a research collaboration with MIT superstar neuroscientist Ed Boyden that MIT just terminated. Although McIntyre's brain preservation techniques are very real and "cutting edge" as is Boyden's neuroanatomical research, the notion of brain uploading to resurrect consciousness is fanciful science fiction. But, the future is not yet written.
We are each a community of 37 trillion cells in dynamic equilibrium with what we eat. So, what should we eat? How many calories per day? How much fat and what kinds of fat? Controversy abounds, but it's essential to get it right. I examine the issue in detail and show you the best videos and articles available free on the internet.
After two years on a very spartan diet, my health took a nosedive. With intolerable dizziness and burning in my feet, I was desperate for an answer.
I got a first clue in 2018 after a lengthy workup. My vitamin B1 (thiamine) had dropped to a dangerously low level.
After taking vitamin B1 supplements my health gradually began to improve, but I wondered "what else might I be low in?"
The answer was "a lot." My blood plasma and WBCs (specifically, lymphocytes) were low in over a dozen intermediary metabolites and other micronutrients. The only way to determine their levels is to measure them in a lab.
Here, I describe the extensive micronutrient panels that I got from two companies: SpectraCell and Vibrant America. If you can get a micronutrient panel cheaply through your health insurance, do that — it's a no-brainer. If you're paying cash, it may still be worth it.
If the "Rapture" is near, we might as well enjoy ourselves while we wait.
The weird and the unusual, especially if set to a catchy tune —
think Weird Al crooning about Donald Trump. (The Donald was a great source of entertainment in 2016 during the Primaries (especially when being endorsed by kindred-loony Sarah Palin.) Now, he's just scary.))
These are my detailed notes on the many lectures I attend every week at Stanford. These frequently feature cutting edge research by faculty, students, and visiting superstars. My WebBrain contains thousands of archived lecture notes (last updated June, 2019).)
I upload a few hundred new lecture notes twice a year: subjects include neuroscience, psychology, AI, cardiology, and molecular biology. (These notes are alway freely available — though not geared for the general public.)
A Repository of 12,000 Links to Cognitive Psychology, AI and Neuroscience (the public half of my 24,000 node private collection.) Also, hundreds of new links on biology and clinical medicine (longevity and nutrition) (updated June, 2019 — News flash: my in vivo brain is still only 1½ quarts, if that.)
Also, see this concise 2016 Stanford News graphic on building a brain.
French biotech Carmat has developed a totally implantable artificial heart — a stunning breakthrough. Although a heart transplant is preferable (if you're one of the few to get a suitable donor heart,) Carmat's device could become the second best option for terminal heart patients — and there are millions. (I also cite competing American biotech makers of left- and bi-ventricular assist devices (Syncardia, Heartware, and Thoratec,) all recently acquired.)
In 2018 Carmat announced it had completed six implants in its PIVOTAL study toward obtaining a CE Mark. All these patients had survived at least one month. As Carmat ramps for European sales, in 2018 they also opened a new, high-volume assembly plant.
On January 15, 2019 in their 2018H2 report they announced that seven of their first ten patients had survived at least six months. Carmat's goal is to recruit ten more patients in 2019 to finish their PIVOTAL trial. They hope to start implanting patients in the USA in 2019 under an FDA IDE.
Atherosclerosis of the coronary arteries (and consequent heart attack) is the number one killer throughout the United States and Europe. If you're a man over 45 or a women over 55, chances are your arteries show signs of atherosclerosis. But how much, and are you a "sitting-duck" waiting to die?
Treadmill tests are woefully insensitive — if your treadmill is positive, it's very late in the game. But, a reliable measure of coronary artery disease can be had by fast CT scan for coronary artery calcification. This is a story with a highly personal angle.
The "ETH Array" is my name for a spectacular CMOS chip developed in the lab of Swiss researcher Andreas Hierlemann, who presented this work in 2016. Our seminar was hosted by Stanford's Professor E. J. Chichilnisky, whose lab is using it to study retinal physiology.
The newest (2016) generation of the chip contains an array of 60,000 electrodes, which can trace the flow of action potentials (spikes) in overlying brain slices in real-time.
This MEA (multi-electrode array) can also simultaneously stimulate the overlying neurons and record synaptic release of neurotransmitters.
Although NAND flash has been a spectacular success (as in Amazon's best selling Samsung 850 Evo SSDs,) two new technologies will soon eclipse it, and even compete with DRAM in speed.
In the works for over a decade, startup Nantero's carbon nanotube (CNT) NRAM (non-volatile memory) will finally hit the market in 2018. With a fresh infusion of $21 million dollars for further development, their CNT NRAM has been licensed by several manufacturers. This will truly be a ground-breaking advance.
Intel and Micron made big waves in 2015 when they announced their 3D XPoint tech. It will be marketed starting in 2017 as Optane, initially for servers and subsequently for high-end gaming PCs.
Both of these new memory techs will help usher in a new world of inexpensive genomics, cutting edge brain simulations, and ubiquitous robots and self-driving cars.
Moore's Law (the doubling of CMOS transistor density every two years) is decelerating, but will it soon hit a brick wall?
To prevent that, Cymer, ASML, and Intel have spent billions developing EUV litho. Although EUV has been a struggle, it's now a matter of when, not if.
EUV may be used in 2017 for critical layers at the 10 nm node, and by 2020 for all layers at the 7nm node.
Are Near Death Experiences (NDEs) real? Yes, the reports are real.
During a hike in the Arizona desert, I interviewed famed NDE researcher Pim van Lommel, who believes these experiences require fundamental revisions in physics.
My answer: "Forget it!" NDEs are hallucinations. Neuroscientists can reproduce them in the lab.
Kevin Kelly is the renowned futurist and founder of Wired magazine. As I looked at the rave reviews for his new non-fiction work, The Inevitable, I wondered, "Are Marc Andreessen, David Pogue, and Chris Anderson just giving the Senior Maverick at Wired his proper obeisance?"
No! This is another home run (as was What Technology Wants) — another magnum opus — this time addressing the phase shift in civilization signaled by the amalgam of internet + seven billion souls.
In June, 2016 at (the renowned) Kepler's Books, I introduced Kevin and his interviewer, New York Times tech columnist, John Markoff to an SRO crowd.
There are perhaps two or three dozen physical constants that characterize the nature of our Universe. Some of these are 1) the speed of light, 2) the strength of gravity, 3) the strength of electromagnetism, 4) the strength of the strong force that binds protons and neutrons (and quarks) together to form atomic nuclei, 5) the relative masses of electrons and protons, 6) the ratio of strengths of electromagnetism to gravity, and so on.
It is widely thought by many physicists that these physical constants have to be very narrowly set to allow for the existence of a Universe that permits life. How did we get so lucky?
Are we alone in the Universe? Whether yes or no, the answer is profoundly significant for humanity. The thousands of exo-planet discoveries by the Kepler Mission persuade me that antimicrobial life is likely out there. As for highly advanced extraterrestrials, that's far less certain.
One of the advantages of living in Silicon Valley is being close to the SETI Institute, whose lectures are open to the public (and available online.) Formerly a part of NASA, SETI is the World's HQ for the search for extraterrestrial intelligence.
Addendum: In 2018 TESS (the Transiting Exoplanet Survey Satellite) launched and is expected to discover thousands of new exoplanets, including hundreds of rocky, Earth-sized planets. This will be followed in 2020 by the James Webb and in 2025 by WFIRST.
A few years ago, I went on a trip to the Brazilian Amazon organized by the Center for Inquiry (CFI.)
CFI advocates the (seemingly outrageous) position that personal beliefs and public policy should be based on scientific evidence.
Our guest speaker on this trip was neuroscience's Explainer-in-Chief, Harvard Professor Steven Pinker, whose many books regularly top the best seller lists.
Neuroscience in the jungle with Steve Pinker — that's what it takes to get me out of town and off my bike.
After Microsoft started their forced cram-downs of Win10 in December, 2015, I thought, "Ah, poo-poo — I'll knuckle under." So, I put a blank SSD into my trusty Win7 tower (the case is always open,) and let MSFT overwrite my venerable Win7.
One of the little nagging problem — I couldn't reliably drag the active window with my mouse. So, I swore at it for a week (there were other problems, too) and then I reinstalled my trusty Win7 (by just plugging in another SSD.)
I did ultimately solve the problem. It's easy, but — really? — this should've been cracked in Microsoft user focus groups. How can they be that stupid? (Answer: Microsoft's got troubles. Look at the stock chart. It's dead money.)
I also show you other little problems that kept me away from Win10 (until now.) Promising browser (Edge) but weirdly limited — solution: Google's Chrome. No good photo editor — solution: IrfanView.
PS: Now (summer, 2016) I like Win10 (a few months into it.)
This (seemingly sci-fi) proposal to map every single spike in every neuron was batted around in mid-2012 by Kavli Foundation scientists. I got wind of it shortly thereafter and circulated it around Stanford, where it understandably aroused considerable skepticism
But, one of the neuroscientists who took it seriously was Professor Bill Newsome, a co-chair of our Stanford Neurosciences Institute.
Roll the clock forward to January, 2013. Unbeknowst to us, this proposal had become the science centerpiece of President Barack Obama's State of the Union — his ten year moonshot.
Next, roll the clock to April, 2013. Professor Newsome gets a call from NIH Director Francis Collins asking him to co-chair the working committee to formally draft the proposal. How was I so clairvoyant? It was just a combination of paying close attention and luck.
In 2012 the (Ray) Kurzweil Accelerating Intelligence (KAI) newsletter ran a major opinion piece by Lt Col Peter Garretson (US Air Force) entitled What our civilization needs is a billion year plan. Here's what made me bristle in that article:
My rebuttal in KAI argues that 1) manned missions — costing 100X the price of science-based launches —are a waste of precious NASA resources better spent on robotic probes and rovers, 2) humanity is already choking off the biosphere — we don't need trillions more in space, and 3) humanity is a stepping stone to the profound intelligences (composition unknown) that may emerge (< 1-2 centuries with luck) that will be the great explorers of space.
PS: The Presidential campaign just past makes the notion of humans writing a billion year plan even more absurd. Humans are only Earth's first attempt at creating advanced tool inventors. From my standpoint, a crucial criterion for evaluating President Trump is whether his actions make a nuclear war, global climate change, or biosphere destruction less likely. Since his ascendancy, The Bulletin of Atomic Scientists warns that he's a ticking time bomb. They've advanced their Doomsday clock closer to midnight.