Diplomate: American Board of Emergency Medicine
Diplomate: American Board of Internal Medicine
Emergency Physician: Kaiser Permanente, Northern California, ret.
Research Associate (1981-1986): Stanford University, Computer Science Dept. and co-Principal Investigator of the RX Project (Stanford University)
Awards from NIH: NLM, NCHSR; NSF; PHS; PReMA; RWJ Fnd; Toyobo Fnd;
PhD: Computer Science and Biostatistics: Stanford University - 1981 The RX Project: Automated Medical Discovery - 1976 to 1986
Post-Doctoral Fellow: Clinical Pharmacology: Stanford University (1976 to 1979)
House Staff and Chief Resident: Internal Medicine: Kaiser Northern California
MD: University of California, San Francisco (MSTP: neuroscience) Regent Scholar
B Sci: Massachusetts Institute of Technology (mathematics) and Hertz Engineering Scholar
I've been fascinated by the neurobiology of consciousness for fifty years.
How is it possible for neural circuits to produce pain, pleasure, and our entire perceived world?
Consciousness is the master illusion — the engineering product of hundreds of millions of years of evolution.
Earlier and easier thresholds are 1) understanding the entirety of the internet and 2) autonomously doing Nobel-level science and engineering in many disciplines.
Is this desirable for planet Earth and our biosphere ? Probably, yes. Humanity's unchecked proliferation has been an unmitigated disaster for our biosphere.
The "ETH Array" is my name for a spectacular CMOS chip developed in the lab of Swiss researcher Andreas Hierlemann, who presented this work in 2016. Our seminar was hosted by Stanford's Professor E. J. Chichilnisky, whose lab is using it to study retinal physiology.
The newest (2016) generation of the chip contains an array of 60,000 electrodes, which can trace the flow of action potentials (spikes) in overlying brain slices in real-time.
This MEA (multi-electrode array) can also simultaneously stimulate the overlying neurons and record synaptic release of neurotransmitters.
This is an outstanding work by one of the world's top researchers of consciousness. Since the death of William James and the ascent of Watson, Thorndike, and Skinner, consciousness has all but disappeared (as a field of study) from American cognitive neuroscience. Europeans, especially the brilliant Stan Dehaene, are leading the current revitalization.
Two new videos have just appeared in the prestigious journal Science. The first is an animation showing the incredible level of detail at the synapse. The second video, based on hundreds of electron micrographs stitched together, shows the impossibly complex ultrastructure of the neuropil: the impenetrable forest surrounding synapses.
The key question is how much of that fine detail must be modeled to replicate the brain's performance. My guess is that much more is required than is accounted for in current brain-inspired AI models.
I'm on the Science Advisory Board of the Brain Preservation Foundation (BPF), which seeks to advance the state of the art by awarding cash prizes for best research. So, what are the prospects? I haven't signed up with Alcor, but ask me again in 2030.
Here, neuroscience MD, PhD candidate Andy McKenzie elicits my opinions. In brief: molecular whole brain preservation may be possible by 2040. Resurrection in silicon may not be possible (if ever) until well after 2100. So, keep eating vegetables and exercising — that's my best advice for now!
By the way, we just awarded our BPF small mammal cash prize to Robert McIntyre, who spearheaded the team at 21st Century Medicine. If you want to see the state of art, get his paper "Aldehyde Stabilized Cryopreservation" in Cryobiology.
We are each a community of 10 trillion cells in dynamic equilibrium with what we eat. So, what should we eat? How many calories per day? How much fat and what kinds of fat? Controversy abounds, but it's essential to get it right. I examine the issue in detail and show you the best videos and articles available free on the internet.
Atherosclerosis of the coronary arteries (and consequent heart attack) is the number one killer throughout the United States and Europe. If you're a man over 45 or a women over 55, chances are your arteries show signs of atherosclerosis. But how much, and are you a "sitting-duck" waiting to die?
Treadmill tests are woefully insensitive — if your treadmill is positive, it's very late in the game. But, a reliable measure of coronary artery disease can be had by fast CT scan for coronary artery calcification. This is a story with a highly personal angle.
If the "Rapture" is near, we might as well enjoy ourselves while we wait.
Like the late-night talk-show hosts, I'm praying for The Donald to link up with Sarah Palin as his running mate — a windfall for comedians.
These are my detailed notes on the many lectures I attend every week at Stanford. These frequently feature cutting edge research by faculty, students, and visiting superstars. My WebBrain contains hundreds of archived lecture notes (last updated January, 2016).) To obtain more recent notes, contact me. Everything is free — I'm big on open access. This research is all paid for by American taxpayers.
A Repository of 8000 Links to Cognitive Psychology, AI and Neuroscience (the public half of my 16,000 node private collection.) Also, hundreds of new links on biology and clinical medicine (longevity and nutrition) (updated January, 2016 — News flash: my in vivo brain is still only 1½ quarts, if that.)
Also, see this concise 2016 Stanford News graphic on building a brain.
Are we alone in the Universe? Whether yes or no, the answer is profoundly significant for humanity. The thousands of exo-planet discoveries by the Kepler Mission persuade me that antimicrobial life is likely out there. As for highly advanced extraterrestrials, that's far less certain.
One of the advantages of living in Silicon Valley is being close to the SETI Institute, whose lectures are open to the public (and available online.) Formerly a part of NASA, SETI is the World's HQ for the search for extraterrestrial intelligence.
Moore's Law (the doubling of CMOS transistor density every two years) is decelerating, but will it soon hit a brick wall?
To prevent that, Cymer, ASML, and Intel have spent billions developing EUV litho. Although EUV has been a struggle, it's now a matter of when, not if.
EUV may be used in 2017 for critical layers at the 10 nm node, and by 2020 for all layers at the 7nm node.
There are perhaps two or three dozen physical constants that characterize the nature of our Universe. Some of these are 1) the speed of light, 2) the strength of gravity, 3) the strength of electromagnetism, 4) the strength of the strong force that binds protons and neutrons (and quarks) together to form atomic nuclei, 5) the relative masses of electrons and protons, 6) the ratio of strengths of electromagnetism to gravity, and so on.
It is widely thought by many physicists that these physical constants have to be very narrowly set to allow for the existence of a Universe that permits life. How did we get so lucky?
Are Near Death Experiences (NDEs) real? Yes, the reports are real.
During a hike in the Arizona desert, I interviewed famed NDE researcher Pim van Lommel, who believes these experiences require fundamental revisions in physics.
My answer: "Forget it!" NDEs are hallucinations. Neuroscientists can reproduce them in the lab.
A few years ago, I went on a trip to the Brazilian Amazon organized by the Center for Inquiry (CFI.)
CFI advocates the (seemingly outrageous) position that personal beliefs and public policy should be based on scientific evidence.
Our guest speaker on this trip was neuroscience's Explainer-in-Chief, Harvard Professor Steven Pinker, whose many books regularly top the best seller lists.
Neuroscience in the jungle with Steve Pinker — that's what it takes to get me out of town and off my bike.
This (seemingly sci-fi) proposal to map every single spike in every neuron was batted around in mid-2012 by Kavli Foundation scientists. I got wind of it shortly thereafter and circulated it around Stanford, where it understandably aroused considerable skepticism
But, one of the neuroscientists who took it seriously was Professor Bill Newsome, a co-chair of our Stanford Neurosciences Institute.
Roll the clock forward to January, 2013. Unbeknowst to us, this proposal had become the science centerpiece of President Barack Obama's State of the Union — his ten year moonshot.
Next, roll the clock to April, 2013. Professor Newsome gets a call from NIH Director Francis Collins asking him to co-chair the working committee to formally draft the proposal. How was I so clairvoyant? It was just a combination of paying close attention and luck.
In 2012 the (Ray) Kurzweil Accelerating Intelligence (KAI) newsletter ran a major opinion piece by Lt Col Peter Garretson (US Air Force) entitled What our civilization needs is a billion year plan. Here's what made me bristle in that article:
My rebuttal in KAI argues that 1) manned missions — costing 100X the price of science-based launches —are a waste of precious NASA resources better spent on robotic probes and rovers, 2) humanity is already choking off the biosphere — we don't need trillions more in space, and 3) humanity is a stepping stone to the profound intelligences (composition unknown) that may emerge (< 1-2 centuries with luck) that will be the great explorers of space.
PS: The current Presidential campaign makes the notion of humans writing a billion year plan even more absurd. Humans are only nature's first attempt at advanced tool-inventors.